Tetraspanin 3 is encoded by the Tspan3 gene, contains 4 transmembrane domains, and is involved in oligodendrocyte migration, and signal transduction. 
Tspan3 is a downstream target of musashi 2 (Msi2). Overexpression of MSI2 is an indicator of poor prognosis in myeloid leukemias. These mice carry a gene trap knock-out allele of the Tspan3 gene. Mice that are homozygous for the targeted mutation are viable and fertile. Almost no gene product (mRNA) is detected by RT-PCR analysis of spleen and whole bone marrow cells from homozygotes. At 6 weeks of age, homozygotes exhibit total bone marrow cell numbers similar to wildtype controls. By 3 months of age, homozygotes exhibit hematopoietic abnormalities, including reduction (27% to 60%) of hematopoietic progenitors and differentiated cells. In serial tumor transplantation, homozygotes displayed a reduced incidence of leukemia compared to wildtype controls.

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This Tspan3 (tetraspanin 3) gene trap strain is useful in studies of leukemogenesis, leukemia development and malignancy.

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B6;129P2-Tspan3<Gt(NPX312)Byg>/ReyaJ Frozen Embryo