Cck-eGFP line 2 BAC transgenic mice have eGFP fluorescent protein expression directed by the mouse cholecystokinin promoter/enhancer regions on the BAC. 
The morphology and distribution of the labeled interneurons across the different brain structures show that the transgene is specifically expressed in the cell sub-populations that normally express the <i>Cck</i> gene; including GABAergic interneuron basket cells (primarily synapse onto cell soma) or double bouquet cells (target dendrites in the amygdala, cortex, hippocampus, hypothalamus and thalamus).
While fluorescence is faint, strong eGFP expression via immunohistochemistry is reported specifically in CCK+ cells. 
<br>Hemizygous mice are viable and fertile with no reported behavioral abnormalities. To date (December 2015), it has not been attempted to make this Cck-eGFP line 2 BAC transgenic strain homozygous. However, the donating investigator reports that the parental strain (Cck-eGFP-miGAD67 line 2 BAC transgenic mice; Stock No. <a href="https://www.jax.org/strain/028592"">028592</a>) is viable and fertile as homozygotes.

The Cck-eGFP line 2 BAC transgenic mouse line has the endogenous mouse cholecystokinin promoter/enhancer regions directing fluorescent reporter expression.  These mice may be useful in studying CCK+ GABAergic interneurons in behavioral and molecular processes, as well as cell-type specific GABAergic disturbances in manifestations of schizophrenia.

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C57BL/6-Tg(Cck-EGFP)2Mirn/J Frozen Embryo