The <i>Syn3</i> gene is a member of the synapsin family of neuronal phosphoproteins, which are associated with neurotransmitter release and neurite outgrowth. Synapsin proteins are associated with autism. Synapsin III localizes to cell bodies, growth cones and presynaptic sites, in contrast to synapsin I and II, which localize only to presynaptic terminals.  

The synapsin III knockout allele has a neo cassette replacing exon 1 of the <i>Syn3</i> gene.  
Homozygous mice exhibit an increase in the recycling pool of synaptic vesicles, a reduction in the amplitude of inhibitory postsynaptic currents (IPSC) and a delay in early axon extension.
Homozygous mice are viable and fertile with no reported reproductive deficiency.  

 


Homozygous synapsin III knockout mice exhibit altered synaptic vesicle trafficking, reduced synaptic depression and delayed axon outgrowth. 

These mice may be useful in studying the role of synapsin III in neurodevelopment.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. The MMRRC site maintains this strain where you can make a purchase.