These “Glowing Head” (GH) transgenic mice express the ffLuc-eGFP (firefly luciferase-Enhanced Green Fluorescent Protein) fusion gene under the control of the rat growth hormone gene promoter. Transgene expression is targeted to the non-immune privileged anterior pituitary and does not interfere with pituitary function, as assessed by serum growth hormone levels. These transgenic mice are immune-tolerant to firefly luciferase and Enhanced Green Fluorescent protein, and can be used as an allograft recipient for labeled syngeneic tumor transplantation, avoiding the effects of xenobiotic/antigenic reporters on testing therapeutic agents. Specifically, this strain may be used with the 4T1 metastatic mammary tumor cell line.  Mice that are hemizygous for the transgene and on the BALB/c background are viable and fertile.  The Donating Investigator has not attempted to make the strain homozygous on the BALB/c background.


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This “Glowing Head” transgenic is also available on a FVB/N genetic background: Stock No. <a href="https://www.jax.org/strain/027665">027665</a>, and a C57BL/6 genetic background: Stock No. <a href="https://www.jax.org/strain/027662">027662</a>.




Use of MICE only available to non-profit entities.

These Glowing Head transgenic mice on the BALB/c background are immunologically tolerant to firefly luciferase and Enhanced Green Fluorescent protein, and can be used as a host for labeled syngeneic tumor transplantation.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

<a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> for more information.

C.FVB-Tg(Gnrhr-luc/EGFP)L8Mrln/LmwJ Frozen Embryo