Adam15 or a disintegrin and metallopeptidase domain 15 (metargidin) encodes a membrane-anchored metalloproteinase. Members of the ADAM family are involved in pathological neovascularization and are associated with cancer, atherosclerosis, RA and osteoarthritis. The Adam15 E>A knockin allele inactivates the catalytically active zinc-dependent metalloprotease domain. Mice homozygous for the mutation are viable and fertile. When injected heterotopically with melanoma cells, Adam15 E>A mice form fewer and smaller tumors than wild-type mice. This strain may be useful for studying the catalytic domain in Adam15 and tumor development.

The Adam15 E>A knockin mice carry a point mutation that inactivates the catalytically active zinc-dependent metalloprotease domain resulting reduced tumor development in a heterotopic tumor injection model.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.