MicroRNAs are an abundant class of small regulatory RNAs that control gene expression at the post-transcriptional level. The miR-181 family of genes (mir-181ab1 (Mir181a-1 - Mir181ab-1; also called Mirc14), mir-181ab2 (Mir181a-2 - Mir181b-2; also called Mirc15) and mir-181cd (Mir181c - Mir181d; also called Mirc16)) produce four nearly identical mature miRNAs (miR-181a, miR-181b, miR-181c and miR-181d) from polycistronic transcripts. 

This targeted mutant strain carries a knockout of the mir-181cd (Mirc16) locus and has not yet been characterized. It has been used as a control in characterizing mir-181ab1 (Mirc14) function in normal T cell development and Notch-induced leukemogenesis (see Stock No. <a href="https://www.jax.org/strain/025872">025872</a>). Despite the overlapping expression of miR-181 miRNAs, mir-181ab1, but not mir-181ab2 and mir-181cd, has been found to control the development of normal thymic T cells and leukemia cells.

MicroRNA mir-181cd (Mir181c-Mir181d; also called Mirc16) is knocked out in this targeted mutant strain. Animals have been used as controls in characterizing mir-181ab1 (Mirc14) function in normal T cell development and Notch-induced leukemogenesis.

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