Tie2-SR-B1 transgenic mice express the scavenger receptor class B, member 1 (Scarb1) under the control of the endothelial-specific receptor tyrosine kinase (Tek) promoter. SCARB1 is involved in the transfer of cholesterol between cells and high density lipoprotein cholesterol (HDLC). Overexpression of SCARB1 in endothelial cells results in decreased forward-facing surface of aortic lesions in mice with diet-induced atherosclerosis on the C57BL/6 background. Transfer of HDL through endothelial cells is approximately 4 fold faster from the apical to basolateral compartment than in the reverse direction. This strain may be useful for studying HDL metabolism and cholesterol trafficking in endothelial cells, and protection against atherosclerosis.

Tie2-SR-B1 transgenic mice express the scavenger receptor class B, member 1 (Scarb1) under the control of the endothelial-specific receptor tyrosine kinase (Tek) promoter. TThis strain may be useful for studying HDL metabolism and cholesterol trafficking in endothelial cells, and protection against atherosclerosis.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.