CRISPR/cas9 endonuclease mediated genome editing of the Tuba4a, tubulin, alpha 4A, gene was used to introduce a 50 nucleotide deletion in the single coding exon. Some mutations in the human TUBA4A are associated with amyotrophic lateral sclerosis. The Tuba4a gene encodes one of the major constituents of microtubules. Homozygous mice are viable and fertile. As the mice are characterized, we will modify the strain description and add phenotype data.

The use of this mouse model is subject to the terms and conditions of the Limited Use Label License from Caribou Biosciences, Inc.

The use of this mouse strain or other product (the "Licensed Product") is subject to the terms and conditions of the Limited License from The Broad Institute.

This CRISPR/Cas9 generated mutant of the Tuba4a gene carries a 50 nucleotide deletion in the single coding exon. These mice may be useful in studies related to the cytoskeleton and amyotrophic lateral sclerosis (ALS).

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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