The Casp8 gene encodes a cysteinyl aspartate protease that is an essential part of the caspase activation cascade leading to TNFRSF6/FAS mediated and TNFRSF1A induced apoptosis. These mice possess loxP sites on either side of exon 3 of the targeted Casp8 gene. Mice that are homozygous for this allele are viable and fertile. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exon 3 deleted in the cre-expressing tissues.

 When bred to a strain with Cre recombinase expression in B cells (see Stock No. <a href="https://www.jax.org/strain/006785">006785</a> for example), this mutant mouse strain may be useful in studies of the role of B cells in innate immunity.

These floxed mutant mice possess loxP sites flanking exon 3 of the Casp8 gene. This strain may be useful for generating conditional mutations in applications related to apoptosis, necrosis, inflammation and immunity.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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