Overview

Also Known As:NSG-Ab^o-DQ8-INSVNTR , NSG-Abo-DQ8-INSVNTR

NSG-Ab⁰-DQ8-INS*VNTR (or NSG-Ab0-DQ8-INS*VNTR) mice are NOD.scid.Il2Rγc^null ("NSG") animals lacking murine MHC class II (Ab⁰), expressing a humanized HLA-DQ8 molecule linked to type 1 diabetes development and a human proinsulin class I variant (INS*VNTR; 26-63 tandem ACAGGGGTGTGGGG repeats) common to individuals with type 1 diabetes. These mice are useful for studying type 1 diabetes, autoimmunity and transplantation.

Donating Investigator

Dr. David Serreze, The Jackson Laboratory

Genetic overview

Genetic Background	Generation

Tg(HLA-DQA1,HLA-DQB1)1Dv

Allele Type
Transgenic (Inserted expressed sequence, Humanized sequence)

H2-Ab1^tm1Doi

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	H2-Ab1	histocompatibility 2, class II antigen A, beta 1

Prkdc^scid

Allele Type	Gene Symbol	Gene Name
Spontaneous	Prkdc	protein kinase, DNA activated, catalytic polypeptide

Il2rg^tm1Wjl

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Il2rg	interleukin 2 receptor, gamma chain

Tg(INS*)172Dvs

Allele Type
Transgenic (Inserted expressed sequence, Humanized sequence)

View Genetics

Research Applications

Immunology, Inflammation and Autoimmunity Research
Research Tools
Internal/Organ Research
Virology Research
Cancer Research
Cardiovascular Research
Hematological Research
Developmental Biology Research

View All Research Applications

Base Price

Starting at:

$2,854.50 Domestic price Cryo Recovery

View Price List

Details

Detailed Description

NSG-Ab⁰-DQ8-INS*VNTR (or NSG-Ab0-DQ8-INS*VNTR) mice are NOD.scid.Il2Rγc^null ("NSG"; Stock No. 005557) animals also lacking murine MHC class II (Ab⁰) that express the HLA-DQ8A transgene (Tg(HLA-DQA1,HLA-DQB1)1Dv) and the INS*VNTR transgene (Tg(INS*)172Dvs).

The following genotype(s) may be collectively referred to as NSG-Ab⁰-DQ8-INS*VNTR mice: females homozygous for scid, Ab⁰, Il2Rγc^null and HLA-DQ8A and hemizygous for the HLA-DQ8A transgene - and males homozygous for scid and Ab⁰, hemizygous for the X-linked Il2Rγc^null, homozygous for HLA-DQ8A and hemizygous for INS*VNTR.

The human insulin gene (INS) is translated into preproinsulin (the precursor of mature insulin), which is processed to proinsulin by removal of the signal peptide and then to mature biologically active insulin by removal of the C-peptide. In the INS promoter region, a variable number tandem repeat (VNTR) region consisting of a 14-15 bp consensus sequence is associated with three classes of alleles: there is a higher frequency of class I alleles with shorter repeat sequences in individuals with Type 1 diabetes, whereas individuals with longer class III alleles are relatively protected from Type 1 diabetes. The VNTR regulates transcription rates of insulin and its precursors. The INS*VNTR transgene derived from founder line 17-2 (172) expresses a human proinsulin class I variant (26-63 tandem ACAGGGGTGTGGGG repeats).

Therefore, the NSG-Ab⁰-DQ8-INS*VNTR mice may be expected to combine the NSG phenotype (Stock No. 005557) and murine MHC class II knockout phenotype, while expressing a humanized HLA-DQ8 molecule linked to Type 1 diabetes development (see Stock No. 026561) - and also expressing a class I variant human proinsulin (INS*VNTR) common to individuals with Type 1 diabetes.

When hemizygous for the INS*VNTR transgene derived from line 17-2 (172), both female and male NSG-Ab⁰-DQ8-INS*VNTR mice show high expression levels of human insulin and human C-peptide in both serum and pancreas.

Stock No. 005557: Although viable and fertile, homozygous NSG mice are immunodeficient: they have no mature T cells or B cells, lack functional natural killer (NK) cells, have reduced numbers of lymphocytes and myeloid dendritic cells, and are deficient in cytokine signaling.

Stock No. 026561: NSG-Ab⁰-DQ8 are viable and fertile. Ab⁰ homozygotes do not express murine major histocompatibility complex (MHC) class II. Human haematopoietic stem cell-engraftment in NSG-Ab⁰-DQ8 mice results in human insulin-specific Foxp3+ Treg-induction upon subimmunogenic vaccination with strong agonistic insulin mimetopes in vivo. These Tregs are stable and show increased expression of Treg signature genes while suppressing effector T cells.

Similar to other immunodeficient strains, maintaining NSG-Ab⁰-DQ8-INS*VNTR mice in high health status (specific pathogen-free) vivaria promotes overall colony health. If NSG-Ab⁰-DQ8-INS*VNTR animals are maintained in low health barrier rooms, the use of medicated water (e.g., sulfatrim/trimethoprim-sulfa or enrofloxacin/Baytril) is suggested to increase overall colony health.

View our
Resources for the NSG mouse model, including discussion forum, immunodeficient model comparison, and categorized, up-to-date references.

Development

NSG-Ab⁰-DQ8-INS*VNTR (or NSG-Ab0-DQ8-INS*VNTR) mice are NOD.scid.Il2Rγc^null ("NSG") animals with the H2-Ab1^tm1Doi knockout allele (Ab⁰),
the HLA-DQ8A transgene (Tg(HLA-DQA1,HLA-DQB1)1Dv)
and the INS*VNTR transgene (Tg(INS*)172Dvs). NSG-Ab⁰-DQ8-INS*VNTR mice harbor several mutations, as described below.

NSG mice are non-obese diabetic animals (NOD/ShiLtJ) harboring the spontaneous severe combined immunodeficiency mutation (Prkdc^scid) on chromosome 16 and the Il2Rγc^null mutation on the X chromosome (Il2rg^tm1Wjl created by Dr. Warren J. Leonard [NIH]). NSG mice are described and available from The Jackson Laboratory Repository as Stock No. 005557.

The "MHC class II knockout" allele (Ab⁰; H2-Ab1^tm1Doi) on chromosome 17 was created by Drs. Diane Mathis and Christophe Benoist (while at INSERM, Strasbourg, France) - see allele description for Stock Nos. 004606 or 010966. Mice with this Ab⁰ mutation on the NOD genetic background were used to assemble Stock No. 026936.

To create the HLA-DQ8A transgene (Tg(HLA-DQA1,HLA-DQB1)1Dv), a 30 kbp DNA fragment containing the DQA*0301 gene [from cosmid H11A] and a 38 kbp DNA fragment containing the DQB*0302 gene [from cosmid X10A] were microinjected into (CBA/J x B10.M)F2 embryos. To establish germline transmission, founders were mated to the B10.M strain. Mice with the HLA-DQ8A transgene on the NOD genetic background were used to assemble Stock No. 026936.

The INS*VNTR transgene (Tg(INS*)172Dvs) was created by the Type 1 Diabetes Repository (Dr. David V. Serreze) at The Jackson Laboratory. A human insulin genomic sequence was obtained with 26-63 tandem ACAGGGGTGTGGGG repeats in its promoter region. The transgene was microinjected into NSG embryos (Stock No. 005557). Mice from founder line 17-2 (172) were established and then bred to NOD-congenic mice harboring the Ab⁰ mutation and the HLA-DQ8A transgene. The resulting NSG-Ab^o-DQ8-INS*VNTR mutant mice were established at The Jackson Laboratory Repository as Stock No. 026936.

The colony is maintained by breeding females homozygous for scid, homozygous for Ab⁰, homozygous for the X-linked Il2Rγc^null, homozygous for HLA-DQ8A and hemizygous or noncarrier for INS*VNTR with males that are homozygous for scid, homozygous for Ab⁰, hemizygous for the X-linked Il2Rγc^null, homozygous for HLA-DQ8A and noncarrier or hemizygous for INS*VNTR.

Expression Data

Expressed Gene	HLA-DQA1, major histocompatibility complex, class II, DQ alpha 1, human
Expressed Gene	HLA-DQB1, major histocompatibility complex, class II, DQ beta 1, human
Site of Expression
Site of Expression
Site of Expression	T and B lymphocytes.
Site of Expression	Primarily lymphoid cells.
Expressed Gene	INS, insulin, human
Site of Expression	Expression of the transgene is found in all primary cilia of the inner ear sensory epithelium.

Control Suggestions

Approximate Controls

Additional Information

Considerations for Choosing Controls

Genetics

Tg(HLA-DQA1,HLA-DQB1)1Dv

Allele Symbol: Tg(HLA-DQA1,HLA-DQB1)1Dv

Allele Name	transgene insertion 1, Chella David
Allele Type	Transgenic (Inserted expressed sequence, Humanized sequence)
Allele Synonym(s)	Abeta⁰.DQ8; DQ8; HLA-DQ8; HLA-DQ8 Tg; HLA-DQA10301/DQB10302; Tg(HLA-DQA1301,HLA-DQB1302)1Dv
Gene Symbol and Name	Tg(HLA-DQA1,HLA-DQB1)1Dv, transgene insertion 1, Chella David
Gene Synonym(s)
Promoter	HLA-DQA1, major histocompatibility complex, class II, DQ alpha 1, human
Promoter	HLA-DQB1, major histocompatibility complex, class II, DQ beta 1, human
Expressed Gene	HLA-DQA1, major histocompatibility complex, class II, DQ alpha 1, human
Expressed Gene	HLA-DQB1, major histocompatibility complex, class II, DQ beta 1, human
Strain of Origin	(CBA/J x B10.M-H2^f)F2
Chromosome	UN
General Note	Flow cytometric analysis of peripheral blood leukocytes (PBL) using a monoclonal antibody to HLA-DQ demonstrated that transgenic mice express the transgenes. 25-40% of the PBLs of mixed-background transgenic mice homozygous for the targeted MHC class II mutation H2-Ab1^tm1Dim express the transgenes. Lymph nodes of such mice contain three-fold the levels of CD4⁺ CD44⁺ T-cells as do those of nontransgenic MHC class II-deficient mice, levels similar to those of class II-sufficient mice. Immunization of transgenic H2-Ab1^tm1Dim homozygous mice with bovine collagen II results in a strong IgG antibody response to the immunogen, and 66% of these mice develop severe, persistent arthritis. (J:88296)
Molecular Note	A 30-kb human genomic DNA fragment containing the entire HLA-DQA10301 gene and a promoter-truncated HLA-DQB10302 gene from cosmid H11A and a 38-kb DNA fragment containing the entire HLA-DQB1*0302 gene from cosmid X10A were coinjected.
Mutations Made By	Chella David, Mayo Clinic

H2-Ab1^tm1Doi

Allele Symbol: H2-Ab1^tm1Doi

Allele Name	targeted mutation 1, Christophe Benoist and Diane Mathis
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	A beta⁰; A^bbeta^-; AB0; Abeta-; Class II⁰; H2-Ab1^tm1Dim; H2-Ab1tm1Doi; II⁰; MHC class II-; MHCII^-; MHC-II-k.o.
Gene Symbol and Name	H2-Ab1, histocompatibility 2, class II antigen A, beta 1
Gene Synonym(s)
Strain of Origin	129S2/SvPas
Chromosome	17
Molecular Note	The second exon was disrupted by the insertion of a neomycin resistance gene. In addition, the ES cell line used was derived from the 129S2/SvPas strain, which carries a deletion in the promoter region of H2-Ea. Consequently, these MHC class II molecule-deficient mice lacked cell surface expression of both class II-A and class II-E MHC proteins.
Mutations Made By	Christophe Benoist, Joslin Diabetes Center

Prkdc^scid

Allele Symbol: Prkdc^scid

Allele Name	severe combined immunodeficiency
Allele Type	Spontaneous
Allele Synonym(s)	SCID
Gene Symbol and Name	Prkdc, protein kinase, DNA activated, catalytic polypeptide
Gene Synonym(s)
Site of Expression	T and B lymphocytes.
Strain of Origin	C.BKa-Igh^b/Icr
Chromosome	16
Molecular Note	A T-to-A transversion point mutation at a position corresponding to codon 4046 (codon 4095 in transcript ENSMUST00000023352.8) created a premature stop codon (p.Y4046*).

Il2rg^tm1Wjl

Allele Symbol: Il2rg^tm1Wjl

Allele Name	targeted mutation 1, Warren J Leonard
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	[KO]gammac; CD132^-; gammac^-; gc^-; Il2rg^tm1Wjll; IL2Rgamma^null
Gene Symbol and Name	Il2rg, interleukin 2 receptor, gamma chain
Gene Synonym(s)
Site of Expression	Primarily lymphoid cells.
Strain of Origin	129S4/SvJae
Chromosome	X
Molecular Note	A neomycin resistance cassette replaced part of exon 3 and all of exons 4 - 8 of the gene, resulting in the loss of most of the extracellular domain and all of the transmembrane and cytoplasmic domains of the protein.
Mutations Made By	Dr. Warren Leonard, NHLBI, NIH

Tg(INS*)172Dvs

Allele Symbol: Tg(INS*)172Dvs

Allele Name	transgene insertion 172, David V Serreze
Allele Type	Transgenic (Inserted expressed sequence, Humanized sequence)
Allele Synonym(s)	INS*VNTR
Gene Symbol and Name	Tg(INS*)172Dvs, transgene insertion 172, David V Serreze
Gene Synonym(s)
Promoter	INS, insulin, human
Expressed Gene	INS, insulin, human
Site of Expression	Expression of the transgene is found in all primary cilia of the inner ear sensory epithelium.
Strain of Origin	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ
Chromosome	UN
Molecular Note	The INSVNTR transgene (Tg(INS)172Dvs) was created by the Type 1 Diabetes Repository (Dr. David V. Serreze) at The Jackson Laboratory. A human insulin genomic sequence was obtained with 26-63 tandem ACAGGGGTGTGGGG repeats in its promoter region.

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Il2rg^tm1Wjl related

Immunology, Inflammation and Autoimmunity Research
- Growth Factors/Receptors/Cytokines
Cancer Research
- Growth Factors/Receptors/Cytokines

Genotype: Prkdc^scid related

Research Tools
- Toxicology Research
  - xenograft/transplant host
- Cancer Research
  - B and T cell deficiency, xenograft/transplant host
Internal/Organ Research
- Lymphoid Tissue Defects
  - B and T cell deficiency
Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
  - B and T cell deficiency
Virology Research
- B and T Cell Deficiency
  - AIDS research tool

Research Tools
- Genetics Research
  - Tissue/Cell Markers: cell marker for bone marrow transplantation
  - Tissue/Cell Markers: transplantation marker for embryonic and adult tissue
- Cancer Research
  - anti-tumor activity
  - tumor immunology
  - hybridoma production
  - myeloma and hybridoma production
  - Leukemia
  - production of B and T cells, antibodies, and hybridomas
  - genes regulating lymphoma development
  - B and T cell deficiency, xenograft/transplant host
  - T cell deficiency
  - xenograft/transplant host
  - production of T cells and hybridoma
  - B, T, and NK cell deficiency, xenograft/transplant host
  - production of B cells and antibodies
  - B cell deficiency
- Developmental Biology Research
  - transplantation marker for embryonic and adult tissue
- Reproductive Biology Research
  - transplantation marker for embryonic and adult tissue
- Immunology, Inflammation and Autoimmunity Research
  - B and T cell deficiency
  - specific complement deficiency
  - T cell deficiency
  - B, T, and NK cell deficiency
  - NK Cell Deficiency
  - Macrophage Deficiency
  - genes regulating susceptibility to infectious disease and endotoxin
  - background strain for histocompatibility congenics
  - T cell deficiency, xenograft/transplant host
  - production of T cell lines and hybridomas
  - B cell deficiency
  - production of B cells and antibodies
  - production of B cells, antibodies T cell lines, and hybridomas
- Cell Biology Research
- Toxicology Research
  - xenograft/transplant host
  - B and T cell deficiency, xenograft transplant host
Cancer Research
- Other
  - tumor metastasis
- Tumor Resistance
- Tumor Suppressor Genes
- Toxicology
  - B and T cell deficiency, xenograft/transplant host
  - xenograft/transplant host
- Growth Factors/Receptors/Cytokines
Immunology, Inflammation and Autoimmunity Research
- CD Antigens, Antigen Receptors, and Histocompatibility Markers
  - genes regulating susceptibility to infectious disease and endotoxin
- T Cell Receptor Signaling Defects
  - B and T cell deficiency, xenograft/transplant host
  - B and T cell deficiency
- Immunodeficiency
  - multiple immune defects
  - specific complement deficiency
  - B and T cell deficiency
  - T cell deficiency
  - Macrophage defects
  - NK Cell Deficiency
  - NK Cell and Cd8 T Cell defects
  - defects in humoral immune responses
  - B cell defects
  - B cell deficiency
  - B, T, and NK cell deficiency
- Immunodeficiency Associated with Other Defects
- Autoimmunity
  - specific complement deficiency
  - B and T cell deficiency
  - B cell deficiency
- Lymphoid Tissue Defects
  - B and T cell deficiency
  - hematopoietic development
- Graft vs. Host Disease
- HLA transgenics
- Inflammation
  - B and T cell deficiency
- Growth Factors/Receptors/Cytokines
Internal/Organ Research
- Lymphoid Tissue Defects
  - T cell deficiency
  - B and T cell deficiency
- Thymus Defects
  - B and T cell deficient
- Adrenal Cortex Defects
  - T cell deficiency
- Thyroid Defects
Virology Research
- B and T Cell Deficiency
  - AIDS research tool
Cardiovascular Research
- Vascular Defects
  - defective macrophage function
Hematological Research
- Hematopoietic Defects
- Immunological Defects
  - B and T cell deficiency
Developmental Biology Research
- Lymphoid Tissue Defects
  - hematopoietic defects
- Internal/Organ Defects
  - hematopoietic defects
  - Lymphoid Tissue Defects
  - adrenal cortex
- Skin and Hair Texture Defects
Endocrine Deficiency Research
- Thyroid Defects
- Adrenal Cortex Defects
- Skin Defects
Dermatology Research
- Skin and Hair Texture Defects

Mammalian Phenotype Terms by Genotype

References

Additional - H2-Ab1^tm1Doi related

Additional - Il2rg^tm1Wjl related

Additional - Prkdc^scid related

Additional - Tg(HLA-DQA1,HLA-DQB1)1Dv related

Additional - Tg(INS*)172Dvs related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- QPCR:Tg(INS*VNTR)#Dvs-qPCR
- Standard PCR:H2-Ab1-Alternate 1
- Probe:Il2rg-PROBE
- End Point Analysis:Prkdc End Point
- QPCR:DQ8 Alpha
- QPCR:DQ8 Beta
- Standard PCR:Tg(INS*VNTR)#Dvs
- Genotyping resources and troubleshooting
Breeding Considerations

The NSG-Ab⁰-DQ8-INS*VNTR (or NSG-Ab0-DQ8-INS*VNTR) live colony is maintained by breeding females homozygous for scid (Prkdc^scid), homozygous for Ab⁰ (H2-Ab1^tm1Doi), homozygous for the X-linked Il2Rγc^null (Il2rg^tm1Wjl), homozygous for HLA-DQ8A (Tg(HLA-DQA1,HLA-DQB1)1Dv) and hemizygous or noncarrier for INS*VNTR (Tg(INS*)172Dvs) with males that are homozygous for scid, homozygous for Ab⁰, hemizygous for the X-linked Il2Rγc^null, homozygous for HLA-DQ8A and noncarrier or hemizygous for INS*VNTR.

Homozygous NSG mice are immunodeficient. As such, and similar to other immunodeficient strains, maintenance in high health status (specific pathogen-free) vivaria promotes overall colony health. If homozygous NSG-Foxn1^null animals are maintained in low health barrier rooms, the use of medicated water (e.g., sulfatrim/trimethoprim-sulfa or enrofloxacin/Baytril) is suggested to increase overall colony health. Also see additional NSG housing information.
- Additional Breeding and Husbandry Support
Mating System
- Female Homozygous for Prkdc^scid, Homozygous for H2-Ab1^tm1Doi, Homozygous for Il2rg^tm1Wjl, Homozygous for Tg(HLA-DQA1,HLA-DQB1)1Dv), Hemizygous for Tg(INS*)172Dvs X Male Homozygous for Prkdc^scid, Homozygous for H2-Ab1^tm1Doi, Hemizygous for Il2rg^tm1Wjl, Homozygous for Tg(HLA-DQA1,HLA-DQB1)1Dv), Noncarrier for Tg(INS*)172Dvs
  Female Homozygous for Prkdc^scid, Homozygous for H2-Ab1^tm1Doi, Homozygous for Il2rg^tm1Wjl, Homozygous for Tg(HLA-DQA1,HLA-DQB1)1Dv), Noncarrier for Tg(INS*)172Dvs X Male Homozygous for Prkdc^scid, Homozygous for H2-Ab1^tm1Doi, Hemizygous for Il2rg^tm1Wjl, Homozygous for Tg(HLA-DQA1,HLA-DQB1)1Dv), Hemizygous for Tg(INS*)172Dv
Citation
When using the NSG-Ab^o-DQ8-INS*VNTR , NSG-Abo-DQ8-INS*VNTR mouse strain in a publication, please cite the originating article(s) and include JAX stock #026936 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Pricing & Availability

Cryo Recovery

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Not-For-Profit & Academic Pricing

Service/Product	Description	Price
	Homozygous for Prkdc<scid>and H2-Ab1<tm1Doi>, Homozygous or Hemizygous for Il2rg<tm1Wjl>, Heterozygous or wildtype for Tg(HLA-DQA1,HLA-DQB1)1Dv Tg(INS*)172Dvs

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.

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Also Known As:NSG-Abo-DQ8-INS*VNTR , NSG-Abo-DQ8-INS*VNTR

Donating Investigator

Genetic overview

Research Applications

Base Price

Detailed Description

Development

Expression Data

Control Suggestions

Approximate Controls

Additional Information

Tg(HLA-DQA1,HLA-DQB1)1Dv

Allele Symbol: Tg(HLA-DQA1,HLA-DQB1)1Dv

H2-Ab1tm1Doi

Allele Symbol: H2-Ab1tm1Doi

Prkdcscid

Allele Symbol: Prkdcscid

Il2rgtm1Wjl

Allele Symbol: Il2rgtm1Wjl

Tg(INS*)172Dvs

Allele Symbol: Tg(INS*)172Dvs

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Il2rgtm1Wjl related

Genotype: Prkdcscid related

Mammalian Phenotype Terms by Genotype

References

Additional - H2-Ab1tm1Doi related

Additional - Il2rgtm1Wjl related

Additional - Prkdcscid related

Additional - Tg(HLA-DQA1,HLA-DQB1)1Dv related

Additional - Tg(INS*)172Dvs related

Genotyping Protocols

Breeding Considerations

Mating System

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Not-For-Profit & Academic Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms Of Use

Additional Use Restrictions Apply

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Also Known As:NSG-Ab^o-DQ8-INSVNTR , NSG-Abo-DQ8-INSVNTR

H2-Ab1^tm1Doi

Allele Symbol: H2-Ab1^tm1Doi

Prkdc^scid

Allele Symbol: Prkdc^scid

Il2rg^tm1Wjl

Allele Symbol: Il2rg^tm1Wjl

Genotype: Il2rg^tm1Wjl related

Genotype: Prkdc^scid related

Additional - H2-Ab1^tm1Doi related

Additional - Il2rg^tm1Wjl related

Additional - Prkdc^scid related