The retinoblastoma 1 (Rb1) gene encodes a tumor suppressor that regulates the cell cycle and terminal differentiation for several cell types.
Widespread deletion of Rb1 results in embryonic lethality due to hematopoietic
and nervous system development defects.
These mice possess loxP sites on either side of exon 19 of the targeted gene. Mice that are homozygous for this allele are viable and fertile. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exon 19 deleted in the cre-expressing tissues.
When bred to a strain with Cre recombinase expression in the brain (under the control of the mouse Gfap gene promoter) and a Trp53 knock out strain, this mutant mouse strain may be useful in studies of medulloblastoma.
When bred to a floxed Trp53 strain and an ovarian intrabursal injection of an adenovirus expressing Cre recombinase, this mutant mouse strain may be useful in studies of ovarian cancer.
When bred to a strain with Cre recombinase expression in the prostatic epithelium (see Stock No. 026563) and an Akap12 knock out strain (see Stock No. 026228), this mutant mouse strain may be useful in studies of prostate cancer (see Stock No. 026229 for the triple mutant line).
