Kif1b (kinesin family member 1B) encodes an N-terminal-type motor protein and is a candidate tumor-suppressor gene involved in the pathogenesis of neuroblastoma. This gene trap mutation abolishes endogenous Kif1b gene function while expressing a B-geo reporter fusion protein from the disrupted locus. Homozygous deletion of Kif1b results in early embryonic lethality. Heterozygotes are grossly normal. Mutant mice may be useful as a lacZ reporter for Kif1b expression or as a knockout model for studying neural development and neurodegenerative diseases.

This gene trap mutation abolishes endogenous Kif1b gene function while expressing a B-geo reporter fusion protein from the disrupted locus. Homozygous deletion of Kif1b results in early embryonic lethality. This strain may be useful for studying neural development and neurodegenerative diseases.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.