This gene trap mutation abolishes endogenous Kif1b gene function while expressing a B-geo reporter fusion protein from the disrupted locus. Homozygous deletion of Kif1b results in early embryonic lethality. This strain may be useful for studying neural development and neurodegenerative diseases.
William G. Kaelin, Dana Farber Cancer Institute
| Genetic Background | Generation |
|---|---|
|
|
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Gene trapped (Reporter, Inserted expressed sequence) | Kif1b | kinesin family member 1B |
