These Tbx1-GFPflox mice possess a loxP-flanked neomycin cassette that prevents expression of a Tbx1 (T-box1)-GFP fusion gene. TBX1 encodes a T-box transcription factor that maps to the center of the human 22q11.2, a region associated with Velo-cardio-facial/ DiGeorge syndrome (VCFS/DGS) syndrome. TBX1 is essential for proper ear and heart development.

Mice that are homozygous for this allele are viable and fertile.
When bred to mice that express tissue-specific Cre recombinase, resulting offspring will overexpress a GFP-tagged TBX1 protein in cre-expressing tissues. Expression of a single copy of Tbx1-GFP partially rescues heart and inner ear defects in Tbx1-null embryos, however, expression of two copies results in postnatal lethality due to cardiac outflow tract defects. This strain may be useful for studying TBX1 and it’s role in neurogenesis, inner ear and heart development.

Tbx1-GFPflox mice conditionally express a GFP-tagged TBX1 protein. TBX1, a T-box transcription factor, is associated with Velo-cardio-facial/ DiGeorge syndrome (VCFS/DGS) syndrome. 
This strain may be useful for studying TBX1 and it’s role in neurogenesis, inner ear and heart development.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.