The BXD#/Rww recombinant inbred (RI) strains originate from crosses between C57BL/6J (000664) females and DBA/2J (000671) males and were generated using a strategy of advanced intercrosses (AI). They may be used to study the genetics of behavioral phenotypes (including alcohol and drug addiction, stress, and locomotor activity) and complex or potentially complex physiologic phenotypes (including differences in organ weight and bone mineral density).
Robert Williams, University of Tennessee Health Science Center
The BXD recombinant inbred (RI) strains are used to study the genetics of behavioral phenotypes including alcohol and drug addiction, stress, and locomotor activity. The BXD set of RI strains also are used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in organ weight and bone mineral density.
The BXD#/Rww set was generated using a strategy of advanced intercrosses (AI). The AI technique produces recombinant RI strains which incorporate approximately twice as many recombinations as the standard RI strains. The addition of the AI BXD RI lines to the existing BXD set creates the largest of the mouse RI mapping panels. This set is useful in QTL mapping and analysis of gene function.
The strain distribution pattern (SDP) for the BXD RI strains is available through the Mouse Genome Informatics
Contributed Data Sets and Gene Network.
Additional tools and information are presented through the Mouse Phenome Database
Specialized Strain Panel Query Form, and
Gene Network .
The BXD160/Rww to BXD186/Rww advanced recombinant inbred (ARI) lines are derived from G8 and G9 advanced intercrosses between the C57BL/6J and DBA/2J progenitor strains generated by Dr. Abraham Palmer in 2008 and donated to Dr. Robert Williams at the University of Tennessee. Crosses sought to miminize common ancestors in each cross although fewer breeding cages per generation were used. This line was donated to The Jackson Laboratory Repository in 2014 by Dr. Robert Williams.
Currently there are no related genes or alleles for this strain.
The BXD strain set is a recombinant inbred and is maintained by sibling mating.
When using the BXD161/RwwJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #025985 in your Materials and Methods section.