These Etv5fl/fl floxed mutant mice possess loxP sites flanking exons 10-11 of the ets variant gene 5 (Etv5) gene. Etv5 is a transcription factor required for cell growth and differentiation found in the brain, ovaries, kidneys, skeletal muscle, lung, and Sertoli cells in the testis. Mice that are homozygous for this allele are viable and fertile. When bred to mice that express tissue-specific Cre recombinase, resulting offspring will have exons 10-11 deleted in the cre-expressing tissues.
For example, when bred to mice deficient of Etv4 and subsequently to mice expressing Cre Recombinase in mesoderm-derived cells (See Stock No. 025520), anterior limb bud of the resulting offspring show ectopic sonic hedgehog expression and mice exhibit a preaxial polydactyly skeletal phenotype.
