Crebbp (CREB binding protein, also known as CBP) is a protein acetyltransferase that is required for normal development and acts as a tumor suppressor. It interacts with a significant percentage of mammalian transcriptional regulatory proteins and mutations in the gene have been found in hematopoietic and epithelial tumors.

Exon 9 of the mouse Crebbp gene is flanked by loxP sites in this conditional mutant strain. Homozygous floxed mice are viable, fertile and have a normal lifespan. Cre-mediated excision of the floxed region results in a knockout allele, as confirmed by immunohistochemistry.

Exon 9 of the mouse Crebbp gene is flanked by loxP sites in this conditional mutant strain that is useful in studies of tumor suppression and transcriptional regulation. Cre-mediated excision of the floxed region results in a knockout allele.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

Typically mice are recovered in 12-16 weeks. <a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> to place an order or for more information.