Crebbp (CREB binding protein, also known as CBP) is a protein acetyltransferase that is required for normal development and acts as a tumor suppressor. It interacts with a significant percentage of mammalian transcriptional regulatory proteins and mutations in the gene have been found in hematopoietic and epithelial tumors.

Exon 9 of the mouse Crebbp gene is flanked by loxP sites in this conditional mutant strain. Homozygous floxed mice are viable, fertile and have a normal lifespan. Cre-mediated excision of the floxed region results in a knockout allele, as confirmed by immunohistochemistry.

Exon 9 of the mouse Crebbp gene is flanked by loxP sites in this conditional mutant strain that is useful in studies of tumor suppression and transcriptional regulation. Cre-mediated excision of the floxed region results in a knockout allele.

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