These Lfngflox mutant mice possess loxP sites flanking exon 2 of the lunatic fringe (Lfng) gene, an N-acetylglucosamine transferase that acts in the Notch signaling pathway. Lfng is expressed in distal lung during saccular development and basal cells in the developing mammary gland. Mice that are homozygous for this allele are viable, fertile, and normal in size. When bred to mice that express tissue-specific Cre recombinase, resulting offspring will have exon 2 deleted in the cre-expressing tissues. This strain may be useful for studying lung alveogenesis, myofibroblast differentiation and basal-like breast cell cancers.

When bred to mice carrying Tg(EIIa-cre)C5379Lmgd, cre-expression in the early embryo results in mice exhibiting defects in lung structure, defective alveolar septation and impaired myofibroblast differentiation.

When bred to mice carrying Tg(MMTV-cre)1Mam, cre-expression in the mammary gland results in mice exhibiting basal-like mammary tumors with accumulation of activated Notch intracellular domain polypeptides.

These Lfngflox mutant mice possess loxP sites flanking exon 2 of the lunatic fringe (Lfng) gene, an N-acetylglucosamine transferase that acts in the Notch signaling pathway. This strain may be useful for studying lung alveogenesis, myofibroblast differentiation and basal-like breast cell cancers.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.