These CRE3 transgenic mice express Cre recombinase under the control of the rat myosin light chain II ventricular (<i>Mylpf</i> or MLC2v) promoter.  Cre activity is observed beginning at E11.5 in the brain and only in cells that are committed to be neurons.  Expression is found in the grey matter of the brain, cerebellum, spinal cord, retina, and dorsal and sympathetic ganglia. No expression is observed in the heart. 
CRE3 mice may be useful for generating conditional deletions in neurons and their progenitors.


These CRE3 transgenic mice express Cre recombinase under the control of the rat myosin light chain II ventricular (<i>Mylpf</i> or MLC2v) promoter beginning at E11.5 in the brain. This strain may be useful for generating conditional deletions in neurons and their progenitors.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. The MMRRC site maintains this strain where you can make a purchase.