B6.NOD-(D11Mit167) H2^g7/DvsJ

Stock number: 024949
Research areas: Diabetes and Obesity Research, Immunology, Inflammation and Autoimmunity Research

Description

These congenic mice were generated by SNP and MIT marker assisted transfer to the B6.NOD-H2^g7 stock of a NOD derived chromosome 11 segment delineated by the marker D11Mit167 (114Mb). The following set of stocks are useful in further characterizing the previously published Idd32 locus (Diabetes 60:1354, 2011) defined by an AI4 T cell transfer protocol where the NOD variant paradoxically contributes to diabetes resistance:

Stock No. 024949; Stock No. 025223; Stock No. 025224.

Detailed description

These congenic mice do not develop spontaneous diabetes. Diabetes develops following infusion of AI4 T-cells, but at lower levels than in standard B6-H2^g7 recipients. The following set of stocks are useful in further characterizing the previously published Idd32 locus (Diabetes 60:1354, 2011) defined by an AI4 T cell transfer protocol where the NOD variant paradoxically contributes to diabetes resistance:

Stock No. 024949; Stock No. 025223; Stock No. 025224.

Development

(B6.NOD-H2^g7xNOD)F2 mice were backcrossed to B6.NOD-H2^g7 mice for 5 additional generations prior to inbreeding to fix the NOD congenic interval marked by D11Mit167 to homozygosity. The current generation is N6F7 (May 2014).

Allele

Symbol: H2^g7
Name: g7 variant
MGI accession ID: MGI:3579321
Generation method: Not Applicable
Marker symbol: H2
Marker name: histocompatibility-2, MHC
Chromosome: 17
Strain of origin: Not Applicable
General note: The g7 variant has been observed in the following strains: DBR7, NON.NOD-H2^g7

Allele

MGI accession ID: MGI:5438776
Marker symbol: Idd32
Marker name: insulin dependent diabetes susceptibility 32
Chromosome: 11

Allele

MGI accession ID: MGI:89053
Marker symbol: D11Mit167
Marker name: DNA segment, Chr 11, Massachusetts Institute of Technology 167
Chromosome: 11