These congenic mice were generated by SNP and MIT marker assisted transfer to the B6.NOD-H2g7 stock of a NOD derived chromosome 11 segment delineated by the marker D11Mit167 (114Mb). The following set of stocks are useful in further characterizing the previously published Idd32 locus (Diabetes 60:1354, 2011) defined by an AI4 T cell transfer protocol where the NOD variant paradoxically contributes to diabetes resistance: Stock No. 024949; Stock No. 025223; Stock No. 025224.
Dr. David Serreze, The Jackson Laboratory
John Driver, University of Florida
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Not Applicable | H2 | histocompatibility-2, MHC |
Marker Symbol | Marker Name | |
---|---|---|
D11Mit167 | DNA segment, Chr 11, Massachusetts Institute of Technology 167 | |
Idd32 | insulin dependent diabetes susceptibility 32 |
These congenic mice do not develop spontaneous diabetes. Diabetes develops following infusion of AI4 T-cells, but at lower levels than in standard B6-H2g7 recipients. The following set of stocks are useful in further characterizing the previously published Idd32 locus (Diabetes 60:1354, 2011) defined by an AI4 T cell transfer protocol where the NOD variant paradoxically contributes to diabetes resistance:
Stock No. 024949; Stock No. 025223; Stock No. 025224.
(B6.NOD-H2g7xNOD)F2 mice were backcrossed to B6.NOD-H2g7 mice for 5 additional generations prior to inbreeding to fix the NOD congenic interval marked by D11Mit167 to homozygosity. The current generation is N6F7 (May 2014).
Allele Name | g7 variant |
---|---|
Allele Type | Not Applicable |
Allele Synonym(s) | H-2g7; H-2g7 |
Gene Symbol and Name | H2, histocompatibility-2, MHC |
Gene Synonym(s) | |
Strain of Origin | Not Applicable |
Chromosome | 17 |
General Note | The g7 variant has been observed in the following strains: DBR7, NON.NOD-H2g7 |
Marker Synonym(s) | |
---|---|
Chromosome(s) | 11 |
Marker Synonym(s) | |
---|---|
Chromosome(s) | 11 |
When maintaining a live colony, these mice can be bred as homozygotes for the congenic segment.
When using the B6.NOD-(D11Mit167) H2g7/DvsJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #024949 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous , 1 pair minimum |
Frozen Mouse Embryo | B6.NOD-(D11Mit167) H2<g7>/DvsJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6.NOD-(D11Mit167) H2<g7>/DvsJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6.NOD-(D11Mit167) H2<g7>/DvsJ Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | B6.NOD-(D11Mit167) H2<g7>/DvsJ Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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