Deformed tail homozygotes have tail kinks, with variability in the number of kinks and variable shortening of the tail length. In the most severe cases the tail is only a short stub. The overall size of the homozygote may be slightly smaller than its littermate controls. Prenatal lethality of some homozygotes is indicated by the smaller litter size and fewer than expected numbers of mutants generated in heterozygous intercrosses, which yielded an average of 13.3% mutants instead of 25%, or crosses between heterozgyotes and homozygotes, which yielded an average of 22.7% mutants instead of 50%. Preliminary mapping linked this mutation to distal Chromosome 5, with only 1 of 9 homozygotes being recombinant with rs3664741.
The mutation deformed tail (dft) arose spontaneously and was identified in an F2 male from an F1 intercross of FVB/NJ with a C57BL/6J-Hrrh-10J/GrsrJ homozygote. This male was bred to a C57BL/6J female and the line was maintained by sibling intercrossing thereafter. Sperm was cryopreserved from homozygous males at generation N1F2 and cryo-recovery is scheduled to use C57BL/6J oocytes.
|Allele Name||deformed tail|
|Allele Type||Spontaneous (Not Specified)|
|Gene Symbol and Name||dft, deformed tail|
|Strain of Origin||C57BL/6J-Hrrh-10J/GrsrJ or FVB/NJ|
|General Note||The mutant phenotype was first observed "in an F2 male from an F1 intercross of FVB/NJ with a C57BL/6J-Hrrh-10J/GrsrJ homozygote." (J:243755)|
|Molecular Note||This recessive mutation arose spontaneously at The Jackson Laboratory.|
When using the B6;FVB-dft/GrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #024840 in your Materials and Methods section.