adipose tissue phenotype

• increased percent body fat/body weight
  • female mutants on a high fat diet display a significant increase in percent body fat compared to female wild-type littermates
  (MGI Ref ID J:89345)

• increased total body fat amount
  • homozygous mice on a high fat diet have significantly increased body fat unlike wild-type mice
  (MGI Ref ID J:89345)

homeostasis/metabolism phenotype

• increased circulating leptin level
  • plasma leptin is increased on both the normal chow and high fat diets in female mutants compared to female wild-type littermates
  (MGI Ref ID J:89345)
  • on a high fat diet plasma leptin is significantly increased in male mutants but not in their male wild-type littermates
  (MGI Ref ID J:89345)

behavior/neurological phenotype

• hyperactivity
  • male homozygous mice display a greater increase in activity with low doses of cocaine compared to male wild-type littermates
  (MGI Ref ID J:43791)

• abnormal cued conditioning behavior
  • male homozygous mice display a significant preference for amphetamines at lower concentrations compared to their male wild-type littermates
  (MGI Ref ID J:43791)

• abnormal food intake
  • only male mutants had a detectable increase in caloric consumption on a high fat diet
  (MGI Ref ID J:89345)

• increased exploration in new environment
  • male homozygous mice display increased activity during the first 5 minutes in a novel environment compared to male wild-type littermates
  (MGI Ref ID J:43791)

growth/size/body region phenotype

• increased susceptibility to weight gain
  • male mutants on a high fat diet have a significant increase in body weight compared to male wild-type littermates or male mutants on a regular diet
  (MGI Ref ID J:89345)

• abnormal body water content
  • male mutants on a high fat diet display a significant increase in water content compared to male wild-type littermates
  (MGI Ref ID J:89345)