Drd3 (dopamine receptor D3) is a G-protein coupled receptor expressed in the limbic system and involved in adenylyl cyclase inhibition. D3 is associated with motor and reward-related behavior. Mice homozygous for this knockout allele are viable and fertile. Drd3-deficient mice exhibit a transient increase in activity in a novel environment, increased activity at low, but not high, doses of cocaine, an altered sensitivity to amphetamine in the conditioned cue preference (CCP) test and enhanced behavioral sensitivity to a combined injection of cocaine and amphetamines (D1 and D2 agonists). This strain may be useful for studying dopamine neurotransmission

These Drd3 knockout mice exhibit altered responses to cocaine (D1 agonist) and amphetamine (D2 agonist) administered separately and together. This strain may be useful for studying dopamine neurotransmission.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.