Drd1a (dopamine receptor D1A) is a G-protein coupled receptor involved in the regulation of neuronal growth and development. The D1 subtype is the most abundant dopamine receptor in the central nervous system. Defects in dopaminergic neurons are associated with Parkinson's disease, schizophrenia, attention-deficit and hyperactivity disorder, and compulsive drug abuse. Mice homozygous for this knockout allele are viable and fertile. Drd1a-deficient mice exhibit reduced body weight, increased locomotor activity, and a loss of response to cocaine administration as well as the stimulant and suppressive effects of D1 agonists and antagonists, respectively. This strain may be useful for studying dopamine neurotransmission.

These Drd1a knockout mice exhibit reduced body weight, increased locomotor activity and a loss of response to D1 agonists and antagonists. This strain may be useful for studying dopamine neurotransmission.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.