The Hif1a (hypoxia inducible factor 1, alpha subunit) gene plays an anti-inflammatory and tissue-protective role by negatively regulating T cell functions. T cell activation leads to up-regulation of the I.1 isoform which represents less than 30% of the total Hif1a mRNA. 

This strain carries a targeted knockout of the I.1 isoform of Hif1a. Isoform I.2 is normally expressed. Unlike the total knockouts of the gene, isolated disruption of the I.1 isoform does not result in embryonic death. Deletion of the isoform is sufficient to markedly enhance TCR-triggered cytokine secretion. Isoform I.1 knockout mice have stronger resistance to bacterial infection. T lymphocytes and macrophages display augmented responses to pathogen. Data suggests the gene is also important for regulation of T cell responses in cancer.

Use of MICE by companies or for-profit entities requires a license prior to shipping.

Hif1a isoform I.1 knockout mice demonstrate an increased resistance to bacterial infection.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

<a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> for more information.