This spontaneous mutation in myosin X causes syndactyly in the front feet, white belly spots, irregular tail pigment, and ocular abnormalities such as persistent hyaloid vasculature, corneal opacity, and iris coloboma
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous (Null/Knockout) | Myo10 | myosin X |
Mice homozygous for the Myo10m1J spontaneous mutation have white spots on the belly and, more rarely, on the back of an otherwise black C57BL/6J coat. They are slightly smaller than normal, often have irregular regions of diminished pigment on the tail, and also have fused digits on either or both of the front feet. This syndactyly has not been found in the digits of the hind feet. Ocular abnormalities caused by this mutation include corneal opacity, iris coloboma, lens spot, and persistent hyaloid vasculature.
The Myo10
Allele Name | mutation 1 Jackson |
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Allele Type | Spontaneous (Null/Knockout) |
Allele Synonym(s) | |
Gene Symbol and Name | Myo10, myosin X |
Gene Synonym(s) | |
Strain of Origin | B6.129S2-Cd4tm1Mak/J |
Chromosome | 15 |
Molecular Note | This is a spontaneous eight nucleotide (CGACGAGT) deletion at chromosome 15 position 25,781,267-274 bp (GRCm38). The deletion disrupts exon 25 and produces a frame shift expected to truncate the full-length and all three headless transcripts following aa 948. Immunoblot of whole brain lysates from 1-month-old mutant mice revealed combined deletion of the full-length and headless forms, confirming complete loss of encoded protein. |
When using the B6.Cg-Myo10m1J/GrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #024583 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Myo10<m1J> |
Frozen Mouse Embryo | B6.Cg-Myo10<m1J>/GrsrJ Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6.Cg-Myo10<m1J>/GrsrJ Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6.Cg-Myo10<m1J>/GrsrJ Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | B6.Cg-Myo10<m1J>/GrsrJ Frozen Embryo | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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