Mutations in MCFD2 (multiple coagulation factor deficiency 2) cause a rare autosomal recessive bleeding disorder called "combined deficiency of coagulation factors V and VIII". Human patients with this disease have low levels of both coagulation factor V (FV or F5) and factor VIII (FVIII or F8). 
Homozygous Mcfd2 knockout mice replicate the human phenotype, as they have decreases in FV and FVIII to approximately 30-50% of the wild type level.

Homozygous Mcfd2 knockout mice replicate the phenotype of a rare autosomal recessive human bleeding disorder called "combined deficiency of coagulation factors V and VIII".

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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