Phosphorylation of Gria1 (glutamate receptor, ionotropic, AMPA1 (alpha 1); also known as GluA1) has been proposed to regulate receptor trafficking and synaptic transmission and plasticity. 
These mice carry S831D and S845D amino acid substitutions in the mouse Gria1 gene that are phosphomimetic (mimic a phosphorylated protein). Mice show normal total and surface expression and subcellular localization of GLUA1 as well as intact basal synaptic transmission. Unlike wildtype animals, mutant mice show long-term potentiation (LTP) induced with a weak 10-Hz stimulation. Evidence indicates that phosphorylation of GLUA1 at S831 and S845 is sufficient to lower the threshold for LTP induction, increasing the probability of synaptic plasticity.

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These mice carry S831D and S845D amino acid substitutions in the mouse Gria1 gene that are phosphomimetic (mimic a phosphorylated protein). Phosphorylation at these amino acids is sufficient to lower the threshold for LTP induction, increasing the probability of synaptic plasticity.

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