BXD125/RwwJ

Stock number: 024031
Research areas: Research Tools

Description

The BXD#/Rww recombinant inbred (RI) strains originate from crosses between C57BL/6J (000664) females and DBA/2J (000671) males. They may be used to study the genetics of behavioral phenotypes (including alcohol and drug addiction, stress, and locomotor activity) and complex or potentially complex physiologic phenotypes (including differences in organ weight and bone mineral density).

Detailed description

The BXD recombinant inbred (RI) strains are used to study the genetics of behavioral phenotypes including alcohol and drug addiction, stress, and locomotor activity. The BXD set of RI strains also are used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in organ weight and bone mineral density. This set is useful in QTL mapping and analysis of gene function.

The strain distribution pattern (SDP) for the BXD RI strains is available through Gene Network and Gene Network2. Genotypes can be downloaded at GeneNetwork BXD Genotype Database. In GeneNetwork, you can select either "classic" genotypes or the new genotypes (BXD104 to BXD220).


Additional tools and information are presented through the Mouse Phenome Database

Specialized Strain Panel Query Form

Development

The BXD113/RwwJ - BXD157/RwwJ lines are derived from the F2 generation between the C57BL/6J and DBA/2J progenitor strains generated at the University of Tennessee. Crosses were initiated using B6D2F1/J mice crossed to generate B6D2F2 mice. At this stage, pairs of F2 animals are chosen at random to serve as the founders for new inbred strains of mice. The offspring from each F2 founder pair are maintained separately from all other offspring, and just two are chosen randomly for brother-sister mating to produce the next generation. These lines was donated to The Jackson Laboratory Repository in 2013 by Dr. Robert Williams.

Allele

Symbol: Taar1^m1J
Name: mutation 1, Jackson
MGI accession ID: MGI:5688955
Generation method: Spontaneous
Attributes: Hypomorph
Marker symbol: Taar1
Marker name: trace amine-associated receptor 1
Chromosome: 10
Strain of origin: DBA/2J
Molecular note: SNP rs33645709, a spontaneously arising C-to-A point mutation identified in DBA/2J, causes a proline to threonine mutation at amino acid position 77 (p.P77T) in the second transmembrane domain near the cytoplasmic side.