The mdx/mTRKO mouse model combines dystrophin-deficiency with telomere dysfunction/shortening, and may be a superior Duchenne muscular dystrophy model as it better recapitulates several of the human characteristics of DMD myopathology (progressive muscle weakness and damage, skeletal muscle fibrosis, diminished muscle stem cell regenerative capacity, dilated cardiomyopathy, heart failure and shortened life-span).
Helen M Blau, Stanford University School of Medicine
Genetic Background | Generation |
---|---|
G0
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Chemically induced (ENU) | Dmd | dystrophin, muscular dystrophy |
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Targeted (Null/Knockout) | Terc | telomerase RNA component |
Starting at:
$278.00 Domestic price for female |
556.00 Domestic price for breeder pair |
Allele Name | X linked muscular dystrophy 4, Verne Chapman |
---|---|
Allele Type | Chemically induced (ENU) |
Allele Synonym(s) | mdx4cv; mdxCv4; mdx4cv; mdx4cv |
Gene Symbol and Name | Dmd, dystrophin, muscular dystrophy |
Gene Synonym(s) | |
Strain of Origin | C3Ha.Cg-Hprta Pgk1a |
Chromosome | X |
Molecular Note | A C to T transition in exon 53 at position 7916 creates a premature stop codon. |
Mutations Made By | Dr. Verne Chapman (deceased), Roswell Park Memorial Institute |
Allele Name | targeted mutation 1, Ronald DePinho |
---|---|
Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | mTerc-; mTR-; Terc-; TR- |
Gene Symbol and Name | Terc, telomerase RNA component |
Gene Synonym(s) | |
Strain of Origin | STOCK 129/Sv and C57BL/6J and SJL |
Chromosome | 3 |
Molecular Note | Replacement of the entire gene with a neomycin cassette. |
Mutations Made By | Dr. Carol Greider, Johns Hopkins Univ School of Medicine |
When using the B6.mdx/mTR mouse strain in a publication, please cite the originating article(s) and include JAX stock #023535 in your Materials and Methods section.
Service/Product | Description | Price |
---|---|---|
Heterozygous or wildtype for Terc<tm1Rdp> , X linked Heterozygous females and wildtype males for Dmd<mdx-4Cv> |
Frozen Mouse Embryo | B6.Cg-Terc<tm1Rdp> Dmd<mdx-4Cv>/BlauJ Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6.Cg-Terc<tm1Rdp> Dmd<mdx-4Cv>/BlauJ Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6.Cg-Terc<tm1Rdp> Dmd<mdx-4Cv>/BlauJ Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | B6.Cg-Terc<tm1Rdp> Dmd<mdx-4Cv>/BlauJ Frozen Embryo | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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