Chromogranin A is a member of the granin family of neuroendocrine secretory proteins and is found in secretory vesicles of neurons and endocrine cells, such as chromaffin cells of the adrenal medulla, paraganglia, enterochromaffin-like cells, beta cells of the pancreas, as well as cardiomyocytes, keratinocytes and granulocytes.  It is co-stored and co-released with catecholamines.  These mice carry a targeted mutation of the <i>Chga</i> (chromogranin A) gene in which exons 1 through 4 are replaced by a NEO cassette.  
Mice that are homozygous for the targeted mutation are viable and fertile.  No gene product (mRNA) is detected by Northern blot analysis of adrenal RNA from homozygotes.  Homozygotes exhibit elevated urine levels of epinephrine, norepinephrine, and dopamine secretion. During backcrossing, the Y chromosome may not have been fixed to the BALB/c genetic background.


<i>Chga</i> knock-out mice exhibit elevated levels of epinephrine, norepinephrine, and dopamine excretion in the urine. 


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