| Allele Name | transgene insertion 1-1, Boris Reizis |
| Allele Type | Transgenic (Recombinase-expressing) |
| Allele Synonym(s) | CD11cCre; Cd11c-cre; CD11cCreT |
| Gene Symbol and Name | Tg(Itgax-cre)1-1Reiz, transgene insertion 1-1, Boris Reizis |
| Gene Synonym(s) | |
| Promoter | Itgax, integrin alpha X, mouse, laboratory |
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| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
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| Site of Expression | most conventional CD11chigh dendritic cells and many plasmacytoid dendritic cells; low expression in lymphocytes, NK cells, and myeloid cells |
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| Strain of Origin | (C57BL/6 x CBA)F1 |
| Chromosome | UN |
| Molecular Note | A transgenic construct containing sequence encoding cre recombinase under the control of the mouse integrin alpha X (Cd11c) promoter, and a bovine growth hormone poly A signal sequence, was introduced into B6CBAF1/J donor eggs. BAC clone RP24-361C4 (BACPAC Resources) containing the Itgax (Cd11c) gene but lacking the 5' end of the adjacent Itgam gene, was modified by ET recombination to generated the transgene construct. Founder line 1-1 was consequently established. Cre recombinase expression is detected in CD8-, CD8+ dendritic cells, tissue derived dendritic cells from lymph nodes, lung and epidermis and plasmacytoid dendritic cells. Background recombination is detected in lymphocytes (<10%) and myeloid cells (<1%). |
| Mutations Made By | Boris Reizis, Columbia University Medical Center |
