Rarb (retinoic acid receptor, beta) gene encodes for a nuclear ligand-dependent transcription factor and is expressed in the developing and adult mouse, particularly in the developing lung and central nervous system. These mice carry a targeted mutation for the Rarb gene in which a NEO cassette replaces exon 6 (encoding the first zinc finger). Mice that are heterozygous for the targeted mutation and on a mixed STOCK background are viable and fertile; it is not known if homozygotes on the STOCK background are viable. On the B6;129 background homozygotes are viable and fertile. No gene product (mRNA) is detected by Northern blot analysis. Homozygotes on the B6;129 background exhibit impaired spatial learning and memory with an absence of hippocampal CA1 region long-term potentiation and long-term depression. When compared to wildtype mice, homozygotes have reduced respiratory function and delayed mammary gland duct development.

This Rarb knockout strain is useful in studies of synaptic plasticity and the role of retinoic acid receptors during development.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

<a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> for more information.