Mice harboring the pR26-228 AR8-TA-mCherry  reporter are viable and fertile, with expression of mCherry under the control of the activin response element from the <i>Xenopus laevis</i> mix1b (Mix.2) promoter. The red fluorescent protein, mCherry, is expressed in cells and tissues that receive SMAD2/3 mediated signaling induced by Nodal/Activin.  The Nodal signal transduction pathway is involved in mesoendoderm induction, patterning of the nervous system, and determination of dorsal- ventral axis in vertebrate embryos.
This strain allows live monitoring of
SMAD2/3-mediated signaling events seen in particular lineages and
stages in embryonic development as well as during regeneration and
homeostasis in adults. Additionally, it allows FACS-based isolation of
responding cells.


Mice harboring the pR26-228 AR8-TA-mCherry reporter express mCherry in cells and tissues that receive SMAD2/3 mediated signaling induced by Nodal/Activin.  
This strain allows live monitoring of
SMAD2/3-mediated signaling events seen in embryonic development as well as during regeneration and
homeostasis in adults. 


This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. The MMRRC site maintains this strain where you can make a purchase.