This bankstock may still be segregating for the Gata1tm6Sho mutation
Mice homozygous for Myo7ash1-13J display extensive head tossing and some head shaking and head bobbing. Their gait can be lower to the ground than normal with the feet held wider apart and the tail often held aloft. They also have an increased tendency to move backward. Circling behavior has not been noted and homozygotes can reproduce and live a normal lifespan.
The Myo5ash1-13J mutation arose spontaneously in the C.129S1(B6)-Gata1tm6Sho/J strain at The Jackson Laboratory. This mutation was maintained by backcross-intercross of homozygous mutant females to BALB/cByJ males for two cycles and was subsequently sibling intercrossed for three generations then again backcross-intercross bred for one cycle before sperm was cryopreserved from homozygous males that had been backcrossed a cumulative total of three times away from the mutant parent strain. Thus, the Gata1tm6Sho mutation may still be present in this frozen sperm and recovered pups will be genotyped for both mutations.
|Allele Name||shaker 1, 13 Jackson|
|Allele Type||Spontaneous (Not Specified)|
|Gene Symbol and Name||Myo7a, myosin VIIA|
|Strain of Origin||C.129S1(B6)-Gata1tm6Sho/J|
|Molecular Note||A spontaneous C to T transition at position 98,097,488 of chromosome 7 (GRCm38/mm10) changes amino acid 212 from arginine to histidine (p.R212H).|
Due to their circling and head tossing behavior, homozygous males should not be present with the pups and heterozygous females are better mothers than are homozygous females.
When using the C.Cg-Myo7ash1-13J/GrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #022311 in your Materials and Methods section.