Atp2c1 or SPCA1 (Ca++ sequestering ATPase) encodes a secretory pathway Ca<2+>-ATPase located in the Golgi. This ATPase mediates Golgi uptake and regulation of cytosolic calcium and magnesium ions. Homozygous embryos do not survive beyond E10.5 as a result of Golgi stress. On a Black Swiss background, embryos exhibit incomplete neural tube closure, diminished Golgi lamellae, dilation of Golgi membranes, increased numbers of Golgi bodies, decreased numbers of ribosomes in the rough ER, increased apoptosis, and an increase in cytoplasmic lipids.
Mice heterozygous for this allele on a mixed 129 and Black Swiss background are viable and fertile, however aged (20+ months) mice have an increased incidence (25%) of squamous cell tumors of keratinized epithelial cells of the skin and esophagus.

This strain may be useful for studying Golgi stress and its role in cancer.
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Aging mice heterozygous for a null Atp2c1 or SPCA1 (Ca++ sequestering ATPase) allele develop an increased incidence (25%) of squamous cell tumors of keratinized epithelial cells of the skin and esophagus. Homozygous embryos do not survive beyond E10.5 as a result of Golgi stress. 


This strain may be useful for studying Golgi stress and its role in cancer.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.