Atp2a2 or SERCA2 (Ca++ transporting ATPase, cardiac muscle, slow twitch 2) encodes an intracellular pump located in the sarcoplasmic or endoplasmic reticula of muscle cells. This ATPase is involved in the cardiac contraction/relaxation cycle and in calcium translocation. Mutations in ATP2A2 are associated with Darier-White disease (keratosis follicularis). Mice heterozygous for this allele are viable and fertile. Homozygous embryos do not survive. Heterozygotes exhibit a reduction in cardiac contractility, reduced blood preesure, susceptibility to cardiac disease in response to
pressure overload, and a reduced force-frequency response in heart. Approximately 90% of aging (50+ weeks) heterozygotes develop squamous cell tumors of keratinized epithelial tissues (including stomach, esophagus, tongue, oral mucosa, and skin). This strain may be useful for studying heart disease and Darier-White disease.

Mice heterozygous for a null Atp2a2 or SERCA2 allele exhibit a reduction in cardiac contractility, reduced blood pressure and squamous cell tumors of keratinized epithelial tissues (90% in aged mice). Homozygous embryos do not survive. This strain may be useful for studying heart disease and Darier-White disease (keratosis follicularis).

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.