This strain is homozygous for Crb1rd8, the retinal degeneration 8 mutation.
Mice homozygous for the Tyrem3J mutation are albino, with a white coat and red eyes. They have a normal lifespan and fertility compared with the parental C57BL/6NJ strain.
This zinc finger induced mutation was generated in C57BL/6NJ one cell embryos and a founder male was bred to C57BL/6NJ females and their offspring were bred to C57BL/6NJ and their offspring were sibling intercrossed at each subsequent generation to generate this line, number 103, that is homozygous for the Tyrem3J mutation, and 8 amino acid in-frame deletion near the middle of the di-copper centre-containing domain.
|Allele Name||endonuclease-mediated mutation 3, Jackson|
|Allele Type||Endonuclease-mediated (Null/Knockout)|
|Gene Symbol and Name||Tyr, tyrosinase|
|Strain of Origin||C57BL/6NJ|
|Molecular Note||This zinc finger mediated allele was generated at The Jackson Laboratory and is a 24 bp deletion of AGGGACCACTATTACGTAATCCTG from Chromosome 7 negative strand position 87,483,953 bp through 87,483,976 bp (GRCm38/mm10), which results in a recessive albino phenotype. This is predicted to cause an 8 amino acid in-frame deletion of amino acids 295-302, GPLLRNPG, near the center of the di-copper centre-containing domain, but is not predicted to cause a premature truncation or frameshift.|
When using the C57BL/6NJ-Tyrem3J/GrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #021999 in your Materials and Methods section.
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