Rhino 10 Jackson provides an additional Hr mutant in that allelic series with a recessive, wrinkly skin, hairless phenotype, which is useful for molecular characterization of the impact of specific sequence variation on HR protein function and resulting phenotype.Read More +
Mice homozygous for the rhino 10 Jackson mutation can be identified by one week of age by their wrinkly skin. In addition, they develop long toenails, small body size, and hairlessness. Homozygotes do grow some hair on their legs, tail, and face but by adulthood they lose even this. They have large, cystic hair follicles, typically seen in Hr mutants. Homozygotes are not good breeders and the best strategy for getting them to breed is to mate them as soon as they are adults and not expect many litters. Heterozygous intercrosses produce fewer than expected homozygotes, less than 8%, indicative of embryonic loss.
The rhino 10 Jackson mutation was identified in the progeny of an ENU mutagenized C57BL/6J male. This recessive mutation has been maintained by backcross-intercross breeding to C57BL/6J so has remained co-isogenic. Sperm was cryopreserved from homozygous males at generation N1.
|Allele Name||rhino 10 Jackson|
|Allele Type||Chemically induced (ENU) (Not Specified)|
|Gene Symbol and Name||Hr, lysine demethylase and nuclear receptor corepressor|
|Strain of Origin||C57BL/6J|
|Molecular Note||This mutation was proven allelic with the rhino allele in the RHJ/LeJ strain by failed complementation testing|
When using the C57BL/6J-Hrrh-10J/GrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #021500 in your Materials and Methods section.