Mir143 (microRNA 143) and Mir145 (microRNA 145) are flanked by loxP sites in this targeted mutation strain, enabling the generation of Cre-mediated, tissue-specific knockouts that affect smooth muscle function.
Dr. Tyler Jacks, Massachusetts Institute of Technology
| Genetic Background | Generation |
|---|---|
|
|
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout) | Mirc32 | microRNA cluster 32, including Mir143 and Mir145a |
