Progranulin or granulin precursor (Grn) is glycopeptide secreted by many cell types and is processed into growth modulating peptides called granulins. The human neurodegenerative syndrome frontotemporal lobar dementia (FTLD) is associated with mutations in progranulin. Progranulin also is associated with wound healing, inflammation, embryogenesis and tumor growth. This targeted mutation deletes exon 2-13 of the mouse progranulin gene, abolishing gene function. Homozygous mice are viable and fertile. Macrophages cultured from Grn-/- mice exhibit increased levels of phagocytosis of apoptopic thymocytes. These mice may be useful in studying the role of progranulin in modulating the kinetics of programmed cell death.

This targeted mutation deletes exon 2-13 of the mouse progranulin (Grn) gene, abolishing gene function. These mice may be useful in studying the role of progranulin in modulating the kinetics of programmed cell death. Progranulin is associated with wound healing, inflammation, embryogenesis, tumor growth, and the human neurodegenerative syndrome frontotemporal lobar dementia (FTLD).

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