The underwhite 7 Jackson mutation is a model of type IV oculocutaneous albinism that causes a dirty white coat color on this otherwise agouti background along with hypopigmentation of the skin and eyes.Read More +
Mice homozygous for the underwhite 7 Jackson mutation have a dirty white colored coat whereas their heterozygous siblings are normal agouti colored. Homozygotes can be identified as pups by their light colored skin compared with heterozygous littermates. The eyes are red, but darken with age.
The underwhite 7 Jackson mutation arose spontaneously in the strain C3H/HeJ-Mfs/J at The Jackson Laboratory in 2011. This mutant subline was backcrossed once to C3H/HeJ and then maintained by intercrossing heterozygotes with homozygotes. The Mfs mutation has never been seen in this mutant subline.
|Allele Name||underwhite 7 Jackson|
|Gene Symbol and Name||Slc45a2, solute carrier family 45, member 2|
|Strain of Origin||C3H/HeJ-Mfs/J|
|Molecular Note||A spontaneous T-to-G point mutation in chromosome 15 position 11023400 (GRCm38), causes tyrosine codon 363 to change to a premature stop codon (p.Y363*).|
When using the C3H/HeJ-Slc45a2uw-7J/GrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #019114 in your Materials and Methods section.