Atp12a or cHKA (H+/K+ transporting, nongastric ATPase, alpha polypeptide) encodes the alpha-subunit of a P-type family of ion transport ATPases found in the colon, kidneys and prostate. cHKA mediates K+ absorption in the colonic epithelium. Homozygous mice are viable and fertile. On a low potassium diet, mice decreased potassium levels in the colon, plasma and muscle (in excess of wild-type) and weight loss. On a low sodium diet, mice exhibit an impaired absorption of sodium and potassium, increased serum aldosterone and increased potassium excretion. cHKA-deficient mice also are associated with loss of acidification of luminal prostate fluids and prostate tumors. This strain may be useful for studying potassium and sodium homeostasis.

On a low potassium diet, Atp12a or cHKA (H+/K+ transporting, nongastric ATPase, alpha polypeptide) homozygous mice exhibit decreased potassium levels in the colon, plasma and muscle (in excess of wild-type) and weight loss. This strain may be useful for studying potassium and sodium homeostasis.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.