A neo cassette replaces exon 1 of the FYN binding protein 1 (<em>Fyb1</em>) gene, abolishing gene expression. FYB1, also known as ADAP (adhesion and degranulation promoting adaptor protein), is expressed in various hematopoietic cell types and is required for slow leukocyte rolling and leukocyte recruitment to areas of inflammation. The number of T cells in these mice is decreased and they display defective T cell receptor (TCR)-mediated adhesion and aggregation. These mice also have decreased numbers of platelets and leukocytes. Homozygotes are viable and fertile.

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These <em>Fyb1</em> knockout mice display defective T cell receptor-mediated adhesion and aggregation. They may have applications in studies related to leukocyte recruitment.

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