In this strain, a neo cassette replaces exon 1 of the potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (<i>Kcnn4</i>) gene, abolishing gene function.  Kcnn4 encodes the calcium-activated intermediate potassium (IK) channel, KCa3.1, in red blood cells, T lymphocytes, and cells in organs involved in salt and fluid transport, including the colon, lung, and salivary glands.  Kcnn4 null mice do not express IK channels in their parotid acinar cells, their red blood cells are not K<sup>+</sup> permeable, and T lymphocytes and erythrocytes exhibit impaired volume regulation.  These mice are protected from developing Crohn's disease and ulcerative colitis in adoptive transfer studies.  Homozygotes are viable and fertile.  

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These mice may be useful for studying the role of calcium-activated intermediate potassium channels on fluid transport, sickle disease, and inflammatory bowel diseases.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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