C57BL/6ByJ-Chr 9^129P3/J/MonMmjax

Stock number: 018681
Product name: C57BL/6ByJ-Chr 9
Research areas: Research Tools

Description

This strain represents one of a panel of chromosome substitution (or consomic) strains. Each strain carries a chromosome from the 129P3/J strain introgressed into a C57BL/6ByJ background. These strains represent a tool for dissection of quantitative trait loci. In particular, these two strains exhibit differences in body composition, alcohol consumption and taste responsiveness. QTL have been identified on Chr 9 at NaCl taste threshold (Nattq2), body weight (Bw16), and adiposity (Adip5).

Detailed description

This strain represents one of a panel of chromosome substitution (or consomic) strains. Each strain carries a chromosome from the 129P3/J strain introgressed into a C57BL/6ByJ background. These strains represent a tool for dissection of quantitative trait loci. In particular, these two strains exhibit differences in body composition, alcohol consumption and taste responsiveness. QTL have been identified on Chr 9 at NaCl taste threshold (Nattq2), body weight (Bw16), and adiposity (Adip5).

Development

Dr. Alexander Bachmanov of the Monell Chemical Senses Center developed this reciprocal consomic set for Chromosomes 1, 2, 7, and 9 by replacing individual chromosomes from the 129P3/J donor strain into the C57BL/6ByJ host strain using a marker-assisted series of backcrosses. The set was donated to the MMRRC at The Jackson Laboratory in 2012.

Allele

Symbol: Bwq6^129P3/J
Name: 129P3/J
MGI accession ID: MGI:2670687
Generation method: QTL
Marker symbol: Bwq6
Marker name: body weight, QTL 6
Chromosome: 9
Strain of origin: 129P3/J
Molecular note: This allele confers decreased body weight compared to C57BL/6ByJ.

Allele

Symbol: Adip20^129P3/J
Name: 129P3/J
MGI accession ID: MGI:2670698
Generation method: QTL
Marker symbol: Adip20
Marker name: adiposity 20
Chromosome: 9
Strain of origin: 129P3/J
Molecular note: This allele confers increased adiposity compared to C57BL/6ByJ.
General note: Adip20 exhibits additive inheritance in the (129P3/J x C57BL/6ByJ)F2 cross.