This strain represents one of a panel of chromosome substitution (or consomic) strains. Each strain carries a chromosome from the 129P3/J strain introgressed into a C57BL/6ByJ background. These strains represent a tool for dissection of quantitative trait loci. In particular, these two strains exhibit differences in body composition, alcohol consumption and taste responsiveness. QTL have been identified on Chr 9 at NaCl taste threshold (Nattq2), body weight (Bw16), and adiposity (Adip5).
Alexander Bachmanov, Monell Chemical Senses Center
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
QTL | Bwq6 | body weight, QTL 6 |
Allele Type | Gene Symbol | Gene Name |
---|---|---|
QTL | Adip20 | adiposity 20 |
This strain represents one of a panel of chromosome substitution (or consomic) strains. Each strain carries a chromosome from the 129P3/J strain introgressed into a C57BL/6ByJ background. These strains represent a tool for dissection of quantitative trait loci. In particular, these two strains exhibit differences in body composition, alcohol consumption and taste responsiveness. QTL have been identified on Chr 9 at NaCl taste threshold (Nattq2), body weight (Bw16), and adiposity (Adip5).
Dr. Alexander Bachmanov of the Monell Chemical Senses Center developed this reciprocal consomic set for Chromosomes 1, 2, 7, and 9 by replacing individual chromosomes from the 129P3/J donor strain into the C57BL/6ByJ host strain using a marker-assisted series of backcrosses. The set was donated to the MMRRC at The Jackson Laboratory in 2012.
Allele Name | 129P3/J |
---|---|
Allele Type | QTL |
Allele Synonym(s) | |
Gene Symbol and Name | Bwq6, body weight, QTL 6 |
Gene Synonym(s) | |
Strain of Origin | 129P3/J |
Chromosome | 9 |
Molecular Note | This allele confers decreased body weight compared to C57BL/6ByJ. |
Allele Name | 129P3/J |
---|---|
Allele Type | QTL |
Allele Synonym(s) | |
Gene Symbol and Name | Adip20, adiposity 20 |
Gene Synonym(s) | |
Strain of Origin | 129P3/J |
Chromosome | 9 |
General Note | Adip20 exhibits additive inheritance in the (129P3/J x C57BL/6ByJ)F2 cross. |
Molecular Note | This allele confers increased adiposity compared to C57BL/6ByJ. |
While maintaining a live colony, these mice are bred as sibling matings.
When using the C57BL/6ByJ-Chr 9 mouse strain in a publication, please cite the originating article(s) and include MMRRC stock #36690 in your Materials and Methods section.
Facility Barrier Level Descriptions
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.