C57BL/6ByJ-Chr 7^129P3/J/MonMmjax

Stock number: 018680
Product name: C57BL/6ByJ-Chr 7
Research areas: Research Tools

Description

This strain represents one of a panel of chromosome substitution (or consomic) strains. Each strain carries a chromosome from the 129P3/J strain introgressed into a C57BL/6ByJ background. These strains represent a tool for dissection of quantitative trait loci. In particular, these two strains exhibit differences in body composition, alcohol consumption and taste responsiveness.

Detailed description

This strain represents one of a panel of chromosome substitution (or consomic) strains. Each strain carries a chromosome from the 129P3/J strain introgressed into a C57BL/6ByJ background. These strains represent a tool for dissection of quantitative trait loci (QTL). In particular, these two strains exhibit differences in body composition, alcohol consumption and taste responsiveness. QTL have been identified on Chr 9 at NaCl taste threshold (Nattq2), body weight (Bw16), and adiposity (Adip5).

Development

Dr. Alexander Bachmanov of the Monell Chemical Senses Center developed this reciprocal consomic set for Chromosomes 1, 2, 7, and 9 by replacing individual chromosomes from the 129P3/J donor strain into the C57BL/6ByJ host strain using a marker-assisted series of backcrosses. The set was donated to the MMRRC at The Jackson Laboratory in 2012.

Allele

Symbol: Ap7q^129P3/J
Name: 129P3/J
MGI accession ID: MGI:2668896
Generation method: QTL
Marker symbol: Ap7q
Marker name: alcohol preference 7 QTL
Chromosome: 7
Strain of origin: 129P3/J
Molecular note: This allele confers decreased intake of 10% ethanol solution compared to DBA/2J.

Allele

MGI accession ID: MGI:2149043
Marker symbol: Adip3
Marker name: adiposity 3
Chromosome: 7