129P3/J-Chr 9^C57BL/6ByJ/MonMmjax

Stock number: 018678
Product name: 129P3/J-Chr 9
Research areas: Research Tools

Description

This strain represents one of a panel of consomic strains. Each strain carries a chromosome from the C57BL/6ByJ strain introgressed into a 129P3/J background. These strains represent a tool for dissection of quantitative trait loci. In particular, these two strains exhibit differences in body composition, alcohol consumption and taste responsiveness.

Detailed description

This strain represents one of a panel of chromosome substitution (or consomic) strains. Each strain carries a chromosome from the C57BL/6ByJ strain introgressed into a 129P3/J background. These strains represent a tool for dissection of quantitative trait loci. In particular, these two strains exhibit differences in body composition, alcohol consumption and taste responsiveness. QTL have been identified on Chr 9 at NaCl taste threshold (Nattq2), body weight (Bw16), and adiposity (Adip5).

Development

Dr. Alexander Bachmanov of the Monell Chemical Senses Center developed this reciprocal consomic set for Chromosomes 1, 2, 7, and 9 by replacing individual chromosomes from the C57BL/6ByJ donor strain into the 129P3/J host strain using a marker-assisted series of backcrosses. The set was donated to the MMRRC at The Jackson Laboratory in 2012.

Allele

Symbol: Bwq6^C57BL/6ByJ
Name: C57BL/6ByJ
MGI accession ID: MGI:2670689
Generation method: QTL
Marker symbol: Bwq6
Marker name: body weight, QTL 6
Chromosome: 9
Strain of origin: C57BL/6ByJ
Molecular note: This allele confers increased body weight compared to 129P3/J.

Allele

Symbol: Adip20^C57BL/6ByJ
Name: C57BL/6ByJ
MGI accession ID: MGI:2670699
Generation method: QTL
Marker symbol: Adip20
Marker name: adiposity 20
Marker synonyms: Adip5
Chromosome: 9
Strain of origin: C57BL/6ByJ
Molecular note: This allele confers increased body weight and body length compared to 129P3/J.
General note: Adip20 exhibits additive inheritance in the (129P3/J x C57BL/6ByJ)F2 cross.