129P3/J-Chr 1^C57BL/6ByJ/MonMmjax

MMRRC Stock No:: 36684-JAX |; 129P3/J-Chr 1

Also Known As: 129P3/J-Chr 1

Donating Investigator

Alexander Bachmanov, Monell Chemical Senses Center

Genetic overview

Genetic Background	Generation

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Research Applications

Research Tools

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Details

Detailed Description

This strain represents one of a panel of chromosome substitution (or consomic) strains. Each strain carries a chromosome from the C57BL/6ByJ strain introgressed into a 129P3/J background. These strains represent a tool for dissection of quantitative trait loci (QTL). In particular, these two strains exhibit differences in taste response, ingestive behavior, alcohol consumption, body size, and adiposity. Genome scans of crosses between these strains have detected QTLs for these phenotypes that cluster on Chr 1, 2, 7 and 9 (Adip2; Adip3, Adip5, Ap7q, Bwq5, Bwq6, Nattq1, Nattq2, Sucq).

In 2013, a 154 SNP (single nucleotide polymorphism) panel analysis covering all 19 chromosomes and the X chromosome was performed at The Jackson Laboratory. All markers on Chr 1 are fixed for the C57BL/6 allele type. The remaining markers are fixed for 129P3/J with the exception of 2 markers on Chr 18 that tested as heterozygous for C57BL/6 and 129P3/J.

Development

Dr. Alexander Bachmanov of the Monell Chemical Senses Center developed this reciprocal consomic set for Chromosomes 1, 2, 7, and 9 by replacing individual chromosomes from the C57BL/6ByJ donor strain into the 129P3/J host strain using a marker-assisted series of backcrosses. The set was donated to MMRRC at The Jackson Laboratory in 2012.

Control Suggestions

000690 129P3/J

Additional Information

Considerations for Choosing Controls

Genetics

Currently there are no related genes or alleles for this strain.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Research Tools
- Genetics Research
  - Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis

Mammalian Phenotype Terms by Genotype

References

Technical Support

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Genotyping Protocols
- Genotyping resources and troubleshooting
Breeding Considerations

While maintaining a live colony, these mice are bred as sibling matings.
- Additional Breeding and Husbandry Support
Citation
When using the 129P3/J-Chr 1 mouse strain in a publication, please cite the originating article(s) and include MMRRC stock #36684 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Terms Of Use

Terms of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

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Animal Care and Use for SERVICES

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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or SERVICES. In addition, special terms and conditions of sale of certain MICE, PRODUCTS, or SERVICES may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and SERVICES by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or SERVICES shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or SERVICES by JACKSON.

Overview