This strain represents one of a panel of chromosome substitution (or consomic) strains. Each strain carries a chromosome from the C57BL/6ByJ strain introgressed into a 129P3/J background. These strains represent a tool for dissection of quantitative trait loci. In particular, these two strains exhibit differences in body composition, alcohol consumption and taste responsiveness.
Alexander Bachmanov, Monell Chemical Senses Center
This strain represents one of a panel of chromosome substitution (or consomic) strains. Each strain carries a chromosome from the C57BL/6ByJ strain introgressed into a 129P3/J background. These strains represent a tool for dissection of quantitative trait loci (QTL). In particular, these two strains exhibit differences in taste response, ingestive behavior, alcohol consumption, body size, and adiposity. Genome scans of crosses between these strains have detected QTLs for these phenotypes that cluster on Chr 1, 2, 7 and 9 (Adip2; Adip3, Adip5, Ap7q, Bwq5, Bwq6, Nattq1, Nattq2, Sucq).
In 2013, a 154 SNP (single nucleotide polymorphism) panel analysis covering all 19 chromosomes and the X chromosome was performed at The Jackson Laboratory. All markers on Chr 1 are fixed for the C57BL/6 allele type. The remaining markers are fixed for 129P3/J with the exception of 2 markers on Chr 18 that tested as heterozygous for C57BL/6 and 129P3/J.
Dr. Alexander Bachmanov of the Monell Chemical Senses Center developed this reciprocal consomic set for Chromosomes 1, 2, 7, and 9 by replacing individual chromosomes from the C57BL/6ByJ donor strain into the 129P3/J host strain using a marker-assisted series of backcrosses. The set was donated to MMRRC at The Jackson Laboratory in 2012.
Currently there are no related genes or alleles for this strain.
While maintaining a live colony, these mice are bred as sibling matings.
When using the 129P3/J-Chr 1 mouse strain in a publication, please cite the originating article(s) and include MMRRC stock #36684 in your Materials and Methods section.
Facility Barrier Level Descriptions
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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