Mice from this strain exhibit head tossing, circling behavior, disorientation in swimming, and deafness. They provide a model for Usher Syndrome, Type 1G.
Read More +Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Ush1g | USH1 protein network component sans |
Mice homozygous for the Jackson shaker 3 Jackson mutation display head tossing and circling behavior and fail to orient in water to swim. Deafness was found at 3 months of age via auditory brainstem response assessment. This mutant provides a model for Usher Syndrome, Type 1G.
The Jackson shaker 3 Jackson mutation arose spontaneously in an NOD congenic strain bearing Prkdcscid and targeted mutations of class 1 histocompatibility genes. This spontaneous mutation was backcrossed onto C57BL/6J and away from the MHC and Prkdcscid mutations. In 2011 this incipient congenic reached backcross generation N6 and was subsequently maintained by sibling intercrossing heterozygous females with homozygous males. Because of the circling phenotype, homozygous females do not make good mothers.
Allele Name | Jackson shaker 3 Jackson |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Ush1g, USH1 protein network component sans |
Gene Synonym(s) | |
Strain of Origin | NOD.Cg-Prkdcscid H2-K1tm1Bpe H2-D1tm1Bpe/Sz |
Chromosome | 11 |
Molecular Note | A single G nucleotide insertion into a string of 6 guanines within exon 2 causes a frame shift with the first 227 amino acids normal, followed by 9 altered amino acids then a premature stop codon. |
When using the Jackson shaker 3 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #018420 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Ush1g<js-3J> |
Frozen Mouse Embryo | B6.Cg-Ush1g<js-3J>/Kjn | $2595.00 |
Frozen Mouse Embryo | B6.Cg-Ush1g<js-3J>/Kjn | $2595.00 |
Frozen Mouse Embryo | B6.Cg-Ush1g<js-3J>/Kjn | $3373.50 |
Frozen Mouse Embryo | B6.Cg-Ush1g<js-3J>/Kjn | $3373.50 |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.