This strain carries multiple undefined mutations identified in a screen of ENU-induced mutations and may be useful in studies of diaphragmatic hernia.
The Jackson Laboratory cannot guarantee that cryorecovery of G1 sperm from the Bench to Bassinet (B2B) collection will be successful or that the anticipated phenotype or genotype will be obtained. The cryorecovery fee for this effort will not be refunded or prorated if the recovery is unsuccessful or is in any way unsatisfactory. Genotyping will be the responsibility of the Purchaser.
Cecilia Lo, Univ of Pittsburgh School of Medicine
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Chemically induced (ENU) | b2b1528Clo | Mutant line 1528 |
This undefined mutation was identified in an ENU screen for recessive cardiovascular development phenotypes in Dr. Cecilia Lo's laboratory, NHLBI Cardiovascular Development Consortium (CvDC). It was recovered from G1 sperm and associated with the phenotype described here. Because G1 sperm were cryopreserved, additional incidental mutations are also segregating in this strain.
Homozygotes demonstrate a non-cardiac phenotype: diaphragmatic hernia.
This undefined mutation, identified in an ENU screen for recessive cardiovascular development phenotypes, was created and maintained on a C57BL/6J genetic background by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program.
Allele Name | Bench to Bassinet Program (B2B/CVDC), mutation 1528 Cecilia Lo |
---|---|
Allele Type | Chemically induced (ENU) |
Allele Synonym(s) | Pokey |
Gene Symbol and Name | b2b1528Clo, Mutant line 1528 |
Gene Synonym(s) | |
Strain of Origin | C57BL/6J |
Chromosome | UN |
General Note | Summative Diagnosis: Noncardiac phenotype: Diaphragmatic hernia |
Molecular Note | This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. |
Heterozygotes are both viable and fertile.
When using the C57BL/6J-b2b1528Clo/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #018183 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
The Jackson Laboratory cannot guarantee that cryorecovery of G1 sperm from the Bench to Bassinet (B2B) collection will be successful or that the anticipated phenotype or genotype will be obtained. The cryorecovery fee for this effort will not be refunded or prorated if the recovery is unsuccessful or is in any way unsatisfactory. Genotyping will be the responsibility of the Purchaser |
Frozen Mouse Embryo | C57BL/6J-b2b1528Clo/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | C57BL/6J-b2b1528Clo/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | C57BL/6J-b2b1528Clo/J Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | C57BL/6J-b2b1528Clo/J Frozen Embryo | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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