Oscar (osteoclast associated receptor) is a collagen receptor, specifically expressed by pre-osteoclasts, that acts as a costimulatory signal for the Fc receptor common gamma (FcRg)-associated pathway required for osteoclastogenesis. 

To better define the role of Oscar in osteoclast differentiation, knockout mice were generated. Animals homozygous for a Oscar knockout do not exhibit any difference in bone volume when compared with wildtype mice.

When the Oscar knockout is combined with a Tyrobp (Dap12) knockout, animals show decreased osteoclast numbers, decreased osteoclast size, and a reduction in eroded bone surfaces as compared to animals homozygous for a Tyrobp targeted mutation. The number and volume of trabeculae in bones is increased. Osteoblast numbers and bone formation parameters are unchanged. 

These mice may be useful in studies of bone remodeling and the pathological bone loss observed in autoimmune diseases, such as osteoporosis and rheumatoid arthritis, and bone cancers.

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These targeted mutation mice carry a functional knockout of the Oscar gene, disrupting a pathways associated with osteoclastogenesis. These mice may be useful in studies of bone remodeling and the pathological bone loss observed in autoimmune diseases, such as osteoporosis and rheumatoid arthritis, and bone cancers.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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